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| 5α-Reductase deficiency ： ウィキペディア英語版 |
5-alpha-reductase deficiency
5α-Reductase deficiency (5-ARD) is an autosomal recessive intersex condition caused by a mutation of the 5α reductase type II gene.
==Normal function==
5α-Reductase is an enzyme that converts testosterone to 5α-dihydrotestosterone (DHT) in peripheral tissues. These enzymes also participate in the creation of such neurosteroids as allopregnanolone and THDOC, convert progesterone into dihydroprogesterone (DHP), and convert deoxycorticosterone (DOC) into dihydrodeoxycorticosterone (DHDOC). 5-ARD is biochemically characterized by low to low-normal levels of testosterone and decreased levels of DHT, creating a higher testosterone/DHT ratio.
DHT is a potent androgen, and is necessary for the development of male external genitalia in utero.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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